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Apolipoprotein H expression is associated with IL28B genotype and viral clearance in hepatitis C virus infection

Melissa E Laird1, Amira Mohsen2, Darragh Duffy1

  • 1Laboratory of Dendritic Cell Immunobiology, Institut Pasteur, Paris, France; INSERM U818, Paris, France.

Journal of Hepatology
|June 7, 2014
PubMed

Insights

Hepatitis C virus (HCV) clearance is linked to higher levels of apolipoprotein H (ApoH). This novel host factor, ApoH, interacts with IL28B genetic variants, influencing treatment response and viral clearance.

Area of Science:

  • Hepatology
  • Virology
  • Immunogenetics

Background:

  • Hepatitis C virus (HCV) replication depends on host lipid metabolism.
  • Apolipoproteins are crucial in the host response to HCV infection and treatment.

Purpose of the Study:

  • To investigate plasma apolipoprotein concentrations in patients with acute and chronic Hepatitis C virus (HCV) infection.
  • To evaluate the association between apolipoproteins and IL28B polymorphisms in relation to HCV clearance.

Main Methods:

  • Plasma apolipoprotein levels were measured in three patient cohorts: acute HCV, chronic HCV undergoing treatment, and HIV/HCV co-infected patients.
  • Associations between apolipoproteins, IL28B polymorphisms (rs12979860 CC SNP), and HCV clearance were analyzed.

Main Results:

  • Higher plasma apolipoprotein H (ApoH) levels were observed in patients achieving spontaneous or treatment-induced HCV clearance.
  • ApoH levels correlated with the IL28B rs12979860 CC single nucleotide polymorphism (SNP) across all cohorts.
  • Both ApoH and IL28B CC SNP were independently associated with HCV clearance, suggesting a shared biological pathway.

Conclusions:

  • Apolipoprotein H (ApoH) is identified as the first protein quantitative trait associated with IL28B genetic variants.
  • ApoH represents a novel host factor influencing Hepatitis C virus (HCV) clearance, potentially mediated by IL28B allele-dependent mechanisms.
Abstract

Keywords:
ApolipoproteinsHepatitis C virusIL28BLipid metabolismQuantitative trait loci

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