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Toward the design of smart delivery systems controlled by integrated enzyme-based biocomputing ensembles
Paula Díez1, Alfredo Sánchez, María Gamella
1Departments of †Analytical Chemistry and ‡Organic Chemistry I, Faculty of Chemistry, Complutense University of Madrid , 28040 Madrid, Spain.
Abstract:
We report herein the design of a smart delivery system in which cargo delivery from capped mesoporous silica (MS) nanoparticles is controlled by an integrated enzyme-based "control unit". The system consists of Janus-type nanoparticles having opposing Au and MS faces, functionalized with a pH-responsive β-cyclodextrin-based supramolecular nanovalve on the MS surface and two effectors, glucose oxidase and esterase, immobilized on the Au face. The nanodevice behaves as an enzymatic logical OR operator which is selectively fueled by the presence of D-glucose and ethyl butyrate.
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