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Updated: Apr 28, 2026
Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
Published on: August 8, 2022
In vitro degradability, bioactivity and cell responses to mesoporous magnesium silicate for the induction of bone
Zhaoying Wu1, Tingting Tang2, Han Guo3
1Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China.
Abstract:
Mesoporous magnesium silicate (m-MS) was synthesized, and the in vitro degradability, bioactivity and primary cell responses to m-MS were investigated. The results suggested that the m-MS with mesoporous channels of approximately 5nm possessed the high specific surface area of 451.0m(2)/g and a large specific pore volume of 0.41cm(3)/g compared with magnesium silicate (MS) without mesopores of 75m(2)/g and 0.21cm(3)/g, respectively. The m-MS was able to absorb a large number of water, with water absorption of 74% compared with 26% for MS. The m-MS was also degradable in a Tris-HCl solution, with a weight loss ratio of 40wt% after a 70-day immersion period. The m-MS exhibited good in vitro bioactivity, inducing apatite formation on its surfaces after soaking in simulated body fluid (SBF) at a faster rate than observed for MS. The m-MS surface clearly promoted the proliferation and differentiation of MC3T3-E1 cells, and their normal cell morphology indicated excellent cytocompatibility. This study suggested that mesoporous magnesium silicate with a high specific surface area and pore volume had suitable degradability and good bioactivity and biocompatibility, making it an excellent candidate biomaterial for the induction of bone regeneration.
Insights
Mesoporous magnesium silicate (m-MS) shows promise for bone regeneration. This biomaterial exhibits enhanced degradability, bioactivity, and excellent cytocompatibility, supporting cell growth and differentiation.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Regenerative Medicine
Background:
- Magnesium silicate (MS) is a potential biomaterial.
- Enhancing its properties is crucial for bone regeneration applications.
- Mesoporous structures can improve material performance.
Purpose of the Study:
- To synthesize mesoporous magnesium silicate (m-MS).
- To investigate the in vitro degradability, bioactivity, and cell responses to m-MS.
- To evaluate m-MS as a candidate for bone regeneration.
Main Methods:
- Synthesis of mesoporous magnesium silicate (m-MS) with ~5nm channels.
- Characterization of surface area (451.0 m²/g) and pore volume (0.41 cm³/g).
- In vitro degradation tests in Tris-HCl solution and bioactivity assessment using simulated body fluid (SBF).
- Cell culture studies with MC3T3-E1 cells to assess proliferation, differentiation, and morphology.
Main Results:
- m-MS demonstrated significantly higher surface area and pore volume than non-mesoporous MS.
- m-MS exhibited enhanced water absorption (74% vs 26%) and controlled degradation (40wt% weight loss over 70 days).
- m-MS showed accelerated apatite formation in SBF and promoted MC3T3-E1 cell proliferation and differentiation with excellent cytocompatibility.
Conclusions:
- Mesoporous magnesium silicate (m-MS) possesses superior physical properties, degradability, bioactivity, and biocompatibility compared to conventional MS.
- The enhanced characteristics of m-MS make it a highly promising biomaterial for inducing bone regeneration.
- m-MS supports cellular functions essential for bone tissue repair and regeneration.
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