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Determination of opiates and other basic drugs by high-performance liquid chromatography with electrochemical
J G Besner1, C Band, J J Rondeau
1University of Montreal, Faculty of Pharmacy, Quebec, Canada.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1989
Abstract:
A procedure is described for the extraction and determination of morphine (M), hydromorphone (HM), codeine (C) and metoclopramide (MCP) present in human plasma. The drugs are separated by reversed-phase liquid chromatography and detected amperometrically at a glassy carbon electrode. The method provides high sensitivity and selectivity and has been used successfully in bioavailability studies.