Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.5K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.5K
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

1.7K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
1.7K
Cellular Adaptation II: Hypertrophy01:26

Cellular Adaptation II: Hypertrophy

52
Hypertrophy is the increase in the size of individual cells, resulting in the enlargement of a tissue or organ. Unlike hyperplasia, which involves an increase in cell number, hypertrophy is characterized by an increase in cell volume. This process often occurs in response to higher functional demand or hormonal stimulation, leading to the production of more structural proteins and organelles, thereby enhancing the cells' work capacity.There are two primary types of hypertrophy:...
52
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

6.1K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of hub genes linking oxidative stress to type 2 diabetic sarcopenia using single-cell sequencing and machine learning.

PloS one·2026
Same author

Clinical effects of surgical delay in older patients with intertrochanteric fractures: analysis from the National Inpatient Sample Database.

BMC geriatrics·2026
Same author

Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)-Enriched Extracellular Vesicles That Promote Angiogenesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Phytohormone dynamics in tomato leaves due to in-situ continuous wearing of sensors.

Plant methods·2026
Same author

The enigmatic role of tumor dormancy cells in gynecologic cancers.

Frontiers in immunology·2026
Same author

Full-fat dairy milk vs. isolated free nutrient blend on postprandial protein metabolism and inflammatory markers in adults with overweight and obesity.

Clinical nutrition ESPEN·2026

Related Experiment Video

Updated: Apr 28, 2026

FACS-Isolation and Culture of Fibro-Adipogenic Progenitors and Muscle Stem Cells from Unperturbed and Injured Mouse Skeletal Muscle
11:25

FACS-Isolation and Culture of Fibro-Adipogenic Progenitors and Muscle Stem Cells from Unperturbed and Injured Mouse Skeletal Muscle

Published on: June 8, 2022

6.2K

Mesenchymal stem cells augment the adaptive response to eccentric exercise.

Kai Zou1, Heather D Huntsman, M Carmen Valero

  • 11Department of Kinesiology and Community Health, University of Illinois, Urbana, IL; 2Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, IL; and 3Division of Biomedical Sciences, University of Illinois, Urbana, IL.

Medicine and Science in Sports and Exercise
|June 7, 2014
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSCs) enhance skeletal muscle adaptation to exercise by boosting satellite cell activity and muscle growth. These findings suggest MSCs play a key role in exercise-induced muscle repair and adaptation.

More Related Videos

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo
09:19

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo

Published on: February 15, 2021

5.4K
Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
10:03

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Published on: January 20, 2014

8.7K

Related Experiment Videos

Last Updated: Apr 28, 2026

FACS-Isolation and Culture of Fibro-Adipogenic Progenitors and Muscle Stem Cells from Unperturbed and Injured Mouse Skeletal Muscle
11:25

FACS-Isolation and Culture of Fibro-Adipogenic Progenitors and Muscle Stem Cells from Unperturbed and Injured Mouse Skeletal Muscle

Published on: June 8, 2022

6.2K
Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo
09:19

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo

Published on: February 15, 2021

5.4K
Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
10:03

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Published on: January 20, 2014

8.7K

Area of Science:

  • Muscle physiology
  • Stem cell biology
  • Exercise science

Background:

  • The α7β1 integrin is crucial for skeletal muscle structure and function.
  • Transgenic mice overexpressing α7B integrin show enhanced responses to exercise.
  • Mesenchymal stem cells (MSCs) accumulate in α7Tg muscle, suggesting a role in adaptation.

Purpose of the Study:

  • To investigate the role of muscle-derived mesenchymal stem cells (mMSCs) in exercise-induced adaptations in skeletal muscle.
  • To determine if mMSCs contribute to the enhanced satellite cell and growth responses observed in α7Tg mice.

Main Methods:

  • Isolated and dye-labeled mMSCs from α7Tg mice were injected into wild-type mice.
  • Recipient mice were subjected to sedentary or eccentric exercise training for 2 or 4 weeks.
  • Muscle tissue was analyzed for cellular changes and fiber characteristics.

Main Results:

  • mMSC transplantation increased satellite cell number and myonuclear content post-exercise.
  • Eccentric exercise with mMSC transplantation led to increased muscle fiber size and grip strength.
  • mMSC transplantation alone did not improve muscle repair or growth without exercise.

Conclusions:

  • Muscle-derived MSCs contribute significantly to satellite cell expansion and muscle growth following eccentric exercise.
  • The accumulation of MSCs in muscle after exercise may enhance adaptive responses.
  • Targeting MSCs could be a strategy to improve exercise-induced muscle adaptation.