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Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
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When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...

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Related Experiment Video

Updated: Apr 28, 2026

Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair

Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair

Published on: March 1, 2024

PTEN.

Carolyn A Worby¹, Jack E Dixon

¹Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0721;

Annual Review of Biochemistry

|June 7, 2014

Summary

This summary is machine-generated.

The tumor suppressor PTEN is crucial for cell function and its deregulation is common in cancer. PTEN

Keywords:

cancer phosphatase tumor suppressor

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Overexpression and Purification of Human Cis-prenyltransferase in Escherichia coli

Overexpression and Purification of Human Cis-prenyltransferase in Escherichia coli

Published on: August 3, 2017

Area of Science:

Biochemistry
Molecular Biology
Oncology

Background:

PTEN (Phosphatase and Tensin homolog) is a critical tumor suppressor.
Its lipid phosphatase activity counteracts PI3K/AKT signaling, regulating cell growth and survival.
PTEN deregulation is frequent in various cancers.

Purpose of the Study:

To review the multifaceted roles of PTEN in cellular functions.
To explore PTEN's regulation at transcriptional and posttranscriptional levels.
To highlight PTEN's emerging significance in non-cancerous diseases.

Main Methods:

Literature review and synthesis of existing research on PTEN.
Analysis of PTEN's enzymatic activity and regulatory mechanisms.
Examination of PTEN's involvement in cancer and other diseases.

Main Results:

PTEN regulates key cellular processes: proliferation, survival, metabolism, architecture, and motility.
PTEN is controlled by transcriptional and posttranscriptional modifications.
PTEN's role extends beyond cancer to diseases like diabetes and autism.

Conclusions:

PTEN is a vital regulator of cellular homeostasis and a key player in oncogenesis.
Understanding PTEN regulation offers therapeutic potential for cancer and other diseases.
Further research into PTEN's complex functions may improve patient outcomes.