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Related Experiment Video

Updated: Apr 28, 2026

The Fabrication and Operation of a Continuous Flow, Micro-Electroporation System with Permeabilization Detection

The Fabrication and Operation of a Continuous Flow, Micro-Electroporation System with Permeabilization Detection

Published on: January 7, 2022

Electroporation-based technologies for medicine: principles, applications, and challenges.

Martin L Yarmush¹, Alexander Golberg, Gregor Serša

¹Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Harvard Medical School and Shriners Burn Hospital for Children, Boston, Massachusetts 02114; email (M.L.Y.): ireis@sbi.org.

Annual Review of Biomedical Engineering

|June 7, 2014

Summary

Electroporation uses electric fields to temporarily increase cell membrane permeability, enabling medical applications. Research advances have translated this technique into clinical use, though challenges remain for wider adoption.

Keywords:

DNA vaccination electrochemotherapy electropermeabilization gene electrotransfer irreversible electroporation pulsed electric field

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Last Updated: Apr 28, 2026

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Area of Science:

Biophysics
Cell Biology
Medical Technology

Background:

Pulsed electric fields increase cell and tissue permeability.
This phenomenon, electroporation, involves temporary aqueous pores in membranes.
Four decades of research have enabled clinical translation.

Purpose of the Study:

Review the theory and current medical applications of electroporation.
Discuss challenges and barriers to broader clinical adoption.

Main Methods:

Literature review of fundamental and experimental electroporation research.
Analysis of current clinical applications and future challenges.

Main Results:

Electroporation is a validated technique with established medical uses.
Significant progress has been made in understanding and applying electroporation.
Barriers to wider clinical spread persist.

Conclusions:

Electroporation is a key technology in modern medicine.
Continued research is needed to overcome challenges and expand clinical applications.