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Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering
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Inertial focusing in microfluidics.

Joseph M Martel1, Mehmet Toner

  • 1BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, Boston, Massachusetts 02114;

Annual Review of Biomedical Engineering
|June 7, 2014
PubMed
Summary
This summary is machine-generated.

Inertial focusing, a phenomenon of particle behavior in fluid flow, is now a rapidly expanding field. This technology enables precise manipulation of bodily fluids for diagnostics and point-of-care applications.

Keywords:
applied physicsbiofluid processinghigh throughputhydrodynamic liftlabel-free cell separationparticle separation

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Area of Science:

  • Fluid dynamics
  • Biophysics
  • Microfluidics

Background:

  • Segré and Silberberg first observed particle congregation in laminar pipe flow in 1961.
  • Decades of research identified unknown forces in inertial flow as the cause.
  • The development of microfluidics revolutionized inertial focusing applications.

Purpose of the Study:

  • To review the theoretical advancements in inertial focusing.
  • To highlight key applications of inertial focusing in diagnostics and fluid processing.
  • To discuss the future potential of inertial focusing as a mainstream technology.

Main Methods:

  • Review of theoretical developments in inertial focusing.
  • Analysis of microfluidic applications for biological fluid and cellular suspension processing.
  • Examination of high-throughput, precise manipulation techniques.

Main Results:

  • Inertial focusing has enabled significant progress in understanding particle behavior in fluid flow.
  • Microfluidics has unlocked new possibilities for inertial focusing in biological applications.
  • Recent advancements facilitate high-throughput, precise manipulation of bodily fluids.

Conclusions:

  • Inertial focusing is a rapidly expanding field with broad applications.
  • The technology is crucial for point-of-care and clinical diagnostics.
  • Inertial focusing is poised to become a mainstream technology in the future.