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Development and applications of CRISPR-Cas9 for genome engineering

Patrick D Hsu1, Eric S Lander2, Feng Zhang3

  • 1Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02141, USA; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

Cell
|June 7, 2014
PubMed
Summary

CRISPR-Cas9 gene editing technology allows scientists to precisely modify DNA sequences. This powerful tool enables researchers to study genome function and understand genetic variations

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