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Updated: Apr 28, 2026

Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Mean platelet volume in schizophrenia unaltered after 1year of clozapine exposure
Jimmy Lee1, Valerie Powell2, Gary Remington3
1Department of General Psychiatry 1, Institute of Mental Health, Singapore, Singapore; Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore; Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Abstract:
This study investigated the MPV of patients with major psychoses before and after 1year of clozapine exposure. Data were obtained from chart reviews of patients who were initiated on clozapine at the Centre of Addiction and Mental Health (CAMH) in Toronto. 100 patients were eligible for this study; 65 remained on clozapine after 1year. Prior to clozapine initiation, MPV was 10.79±0.91fL and there was no difference in MPV after 1year of clozapine exposure (p=0.777). We found high MPV in patients with schizophrenia and related psychoses, which was unaltered after 1year of clozapine treatment.
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