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Low expression of activating transcription factor 3 in human hepatocellular carcinoma and its clinicopathological
Li Xiaoyan1, Zang Shengbing1, Zhang Yu1
1Department of Pathology and Institute of Oncology, Fujian Medical University, Fuzhou 350004, PR China.
Background And Aim:
To explore the expression and role of activating transcription factor 3 in human hepatocellular carcinoma.
Methods:
Immunohistochemistry, Western blot assay and Real-time PCR were used to evaluate activating transcription factor 3 protein and gene level in HCC clinical samples.
Results:
Activating transcription factor 3 expression is lowest in HCC, and the protein level is lower in patients with capsule invasion, while there is no association with other main clinical pathological features.
Conclusions:
Low expression of ATF3 may function as a tumor suppressor during human hepatocellular oncogenesis and targeting ATF3 pathway might be beneficial for anti-HCC therapy.
