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Updated: Apr 28, 2026

Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
Ameloblastic carcinoma developing in preexisting ameloblastoma with a mutation of the p53 gene: a case report
Aiko Nobusawa1, Takaaki Sano2, Satoshi Yokoo3
1Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan; Department of Stomatology and Maxillofacial Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Objective:
Ameloblastic carcinoma is a rare malignant odontogenic tumor. Here we present a case of a large ameloblastic carcinoma, which developed in a preexisting ameloblastoma in the right submandibular region.
Study Design:
The patient was an 84-year-old woman who had received several surgical procedures for ameloblastoma, including a segmental mandibulectomy. The dimensions of the tumor were 12 × 8 × 5 cm, and both benign ameloblastoma and ameloblastic carcinoma were observed histologically. Based on histologic diagnosis, immunohistochemical staining and sequence analysis for p53 were performed.
Results:
Overexpression of p53 was observed only in the ameloblastic carcinoma. Additionally, a mutation of the p53 gene (TP53) in exon 5 was found by sequence analysis in the ameloblastic carcinoma.
Conclusions:
This is the first case of ameloblastic carcinoma with a mutation of the p53 gene that has been associated with carcinomatous transformation.
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