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How population growth affects linkage disequilibrium.

Alan R Rogers1

  • 1Department of Anthropology, University of Utah, Salt Lake City, Utah 84112 rogers@anthro.utah.edu.

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|June 8, 2014
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Summary
This summary is machine-generated.

Population size changes impact linkage disequilibrium (LD) curves. Population expansion steepens the LD curve, while shrinkage flattens it, offering insights into demographic history.

Keywords:
admixturelinkage disequilibriumpopulation growthselection

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Area of Science:

  • Population Genetics
  • Genomics
  • Evolutionary Biology

Background:

  • Linkage disequilibrium (LD) describes the non-random association of alleles at different loci.
  • The LD curve, plotting LD against physical distance, is influenced by evolutionary forces.
  • Understanding LD curve dynamics is crucial for inferring population history.

Purpose of the Study:

  • To investigate how changes in population size affect the LD curve.
  • To derive new theoretical results concerning the relationship between population size history and LD patterns.
  • To explore the utility of LD statistics for reconstructing past demographic events.

Main Methods:

  • Theoretical derivation of LD curve behavior under varying population size scenarios.
  • Analysis of LD convergence dynamics.
  • Examination of different LD statistics and their sensitivity to demographic changes.

Main Results:

  • Population expansion leads to a steeper LD curve, particularly after a population bottleneck.
  • Population contraction results in a flatter, rising LD curve.
  • The time path of LD convergence to equilibrium may be non-monotonic, with some statistics (like estimates of [Formula: see text]) converging slowly, enabling inference of ancient population history.
  • Analysis of European human population data suggests a history of population growth.

Conclusions:

  • The LD curve is a sensitive indicator of population size history.
  • Specific LD statistics provide valuable tools for reconstructing ancient demographic events.
  • The findings support a model of population growth for the human population of Europe.