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Leukocyte margination at arteriole shear rate
Naoki Takeishi1, Yohsuke Imai2, Keita Nakaaki2
1Department of Biomedical Engineering, Tohoku University, AobaSendai, Japan.
Physiological Reports
|June 8, 2014
Summary
Passing red blood cells (RBCs) effectively drive leukocyte margination in small and large arteriole channels. This margination is sustained, even though larger channels require more time to initiate.
Area of Science:
- Biomedical Engineering
- Fluid Dynamics
- Cellular Biology
Background:
- Leukocyte margination is crucial for immune cell trafficking to tissues.
- Understanding margination dynamics in microvessels is key to comprehending inflammatory responses.
Purpose of the Study:
- To numerically investigate leukocyte margination in arteriole-sized channels.
- To determine the influence of red blood cell (RBC) motion on leukocyte margination across varying channel diameters.
Main Methods:
- Numerical simulations of fluid flow and particle dynamics.
- Modeling of leukocyte and RBC interactions in straight circular channels (10-22 μm diameter).
- Analysis of margination behavior at arteriole shear rates.
Main Results:
- RBC motion effectively induces leukocyte margination in both small and large channels.
- Margination time increases with channel diameter, but sustained margination is observed.
- Leukocytes rarely approach the wall within a microvillus length at arteriole shear rates.
Conclusions:
- Leukocyte margination is a robust phenomenon driven by RBC flow in microvessels.
- The findings provide insights into immune cell behavior in the microcirculation.
- Sustained margination suggests efficient delivery of leukocytes to vessel walls.
