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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

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Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
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Updated: Apr 28, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Drug delivery vehicles on a nano-engineering perspective.

Betiana Felice1, Molamma P Prabhakaran2, Andrea P Rodríguez3

  • 1Laboratorio de Medios e Interfases, Departamento de Bioingeniería, Universidad Nacional de Tucumán, Av. Kirchner 1800, Tucumán, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. Rivadavia 1917, Buenos Aires, Argentina.; START - Thrust 3, Create Research Wing, #03-08, 1 Create Way, National University of Singapore, Singapore 138602.

Materials Science & Engineering. C, Materials for Biological Applications
|June 9, 2014
PubMed
Summary

Nanoengineered drug delivery systems (nDDS) enhance drug delivery and targeting. Optimizing biomaterial, size, and manufacturing is key for successful clinical applications of these cancer-fighting nanocarriers.

Keywords:
Liposomesbiodegradable polymerscancercontrolled releasenanotechnologytargeted drug delivery

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Materials Science

Background:

  • Nanoengineered drug delivery systems (nDDS) are established clinical tools.
  • They modulate drug release profiles and target diseased tissues.
  • Liposomes and polymer-drug conjugates are common nDDS for anti-cancer drugs like paclitaxel, vincristine, and doxorubicin.

Purpose of the Study:

  • To review nDDS from an engineering perspective.
  • To identify critical parameters for designing successful nDDS.
  • To discuss manufacturing techniques for clinical and industrial scale-up.

Main Methods:

  • Review of existing literature on nDDS design and manufacturing.
  • Analysis of factors influencing drug release profiles.
  • Evaluation of various fabrication techniques for nDDS.

Main Results:

  • Successful nDDS design requires careful selection of biomaterial, size, architecture, and degradation mechanisms.
  • Manufacturing techniques must be chosen to maintain the desired release profile and allow for scalability.
  • Optimization of these factors is crucial for clinical success.

Conclusions:

  • Engineering considerations are vital for developing effective nDDS.
  • A multidisciplinary approach optimizing design and manufacturing ensures successful clinical translation.
  • Future nDDS development should focus on these engineering principles for broader industrial application.