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Drug delivery property, bactericidal property and cytocompatibility of magnetic mesoporous bioactive glass

Yi-Zhuo Liu1, Yang Li2, Xi-Bin Yu1

  • 1The Education Ministry Key Lab of Resource Chemistry, Shanghai Normal University, Shanghai 200234, PR China; Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, PR China.

Materials Science & Engineering. C, Materials for Biological Applications
|June 9, 2014
PubMed

Insights

Magnetic mesoporous bioactive glass (MMBG) enhances drug delivery and biocompatibility. This material shows potential for treating implant-associated infections by minimizing bacterial adhesion and promoting cell functions.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Mesoporous bioactive glass (MBG) is used for drug delivery, but its biological properties require further investigation.
  • Magnetic nanoparticles (Fe3O4) can enhance material functionalities.
  • Understanding the combined effects of mesopores and magnetic nanoparticles is crucial for optimizing bioactive glass applications.

Purpose of the Study:

  • To investigate the impact of mesopores and Fe3O4 nanoparticles on the drug loading-release, bactericidal, and biocompatibility properties of bioactive glass.
  • To compare the performance of multifunctional magnetic mesoporous bioactive glass (MMBG) with mesoporous bioactive glass (MBG) and non-mesoporous bioactive glass (NBG).

Main Methods:

  • Synthesis and characterization of MMBG, MBG, and NBG.
  • Evaluation of drug loading and release kinetics (e.g., gentamicin).
  • Assessment of bactericidal properties against Staphylococcus aureus and Staphylococcus epidermidis.
  • In vitro biocompatibility testing, including cell adhesion, spreading, and proliferation assays.

Main Results:

  • MMBG and MBG exhibited superior drug loading efficiency compared to NBG due to their mesoporous structure, high surface area, and pore volume.
  • Fe3O4 nanoparticles in MMBG improved sustained drug release and provided magnetic properties.
  • Gentamicin-loaded MMBG (Gent-MMBG) significantly reduced bacterial adhesion and prevented biofilm formation.
  • MMBG promoted cell adhesion, spreading, and proliferation, indicating excellent biocompatibility.

Conclusions:

  • MMBG demonstrates enhanced drug delivery capabilities and improved sustained release profiles.
  • The incorporation of Fe3O4 nanoparticles in MMBG enhances its therapeutic potential by combining magnetic properties with drug delivery and antibacterial effects.
  • Gent-MMBG shows significant promise for the treatment of implant-associated infections due to its excellent biocompatibility and antimicrobial efficacy.
Keywords:
Bactericidal propertyBiocompatibilityDrug delivery systemMagnetic propertyMesoporous bioactive glass

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