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Updated: Apr 28, 2026
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Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
Published on: February 23, 2024
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The pig as an experimental model for mid-dermal burns research
Shi-Yuan Sheu1, Wen-Ling Wang2, Yuan-Tsung Fu3
1School of Chinese Medicine, China Medical University, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Summary
A new device accurately creates experimental burn wounds in pigs. Burn depth in collagen correlates strongly with infliction temperature, validating this model for testing wound healing therapies.
Area of Science:
- Biomedical Engineering
- Dermatology
- Veterinary Science
Background:
- Developing reliable experimental burn models is crucial for wound healing research.
- Existing methods may lack precision in controlling burn depth and severity.
- A standardized, reproducible burn infliction device is needed.
Purpose of the Study:
- To develop and evaluate a novel infliction device for creating experimental burn models in pigs.
- To establish a reproducible method for inflicting controlled thermal injuries.
- To assess the correlation between infliction parameters and burn severity.
Main Methods:
- A prospective, interventional animal study using anesthetized pigs.
- A custom device applied a heated stainless steel bar (80-110°C, 1kgf, 20s) to create 36mm diameter burns.
- Macroscopic and histopathological evaluations were performed over 24 days.
- Biopsies analyzed collagen denaturation depth (Seg1) and correlated with infliction temperature (Ti).
Main Results:
- A high correlation was found between burn infliction temperature and histopathological assessment.
- The depth of injury to collagen (Seg1) strongly correlated with temperature (Ti): Seg1=0.038Ti-2.57 (r=0.973, P<0.05).
- Histological studies confirmed a high correlation between collagen denaturation depth and exposure temperature: Seg1=0.0268Ti-0.165 (r=0.991, P<0.05).
Conclusions:
- The novel infliction device reliably creates experimental burn wounds in pigs.
- The model demonstrates a strong correlation between infliction temperature and burn depth.
- This validated model is suitable for evaluating therapeutic agents in experimental burn wound healing.
