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[Renal denervation for treating hypertension: experience at the University Hospital in Lyon]

P-Y Courand1, R Dauphin1, O Rouvière2

  • 1Service de cardiologie, hôpital de la Croix-Rousse, hospices civils de Lyon, 103, grande rue de la Croix-Rousse, 69004 Lyon, France; EA 4173, génomique fonctionnelle de l'hypertension artérielle, université Claude-Bernard Lyon1, 69100 Villeurbanne, France; Hôpital Nord-Ouest, 69400 Villefranche sur Saône, France.

Annales De Cardiologie Et D'Angeiologie
|June 9, 2014
PubMed

Insights

Renal denervation significantly lowered blood pressure in patients with resistant essential hypertension. This safe procedure showed notable reductions in both office and ambulatory blood pressure measurements.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Hypertension Management

Background:

  • Resistant essential hypertension poses a significant cardiovascular risk.
  • Limited treatment options exist for patients with refractory hypertension.
  • Renal denervation is an emerging therapeutic option.

Purpose of the Study:

  • To evaluate the initial experience with renal denervation for resistant essential hypertension at Lyon's university hospital.
  • To assess the safety and efficacy of renal denervation in this patient cohort.

Main Methods:

  • Seventeen patients with resistant essential hypertension underwent renal denervation over one year.
  • Baseline characteristics included age, BMI, and extensive anti-hypertensive treatment.
  • Follow-up included office and ambulatory blood pressure monitoring.

Main Results:

  • No intra-operative or early complications were observed.
  • Significant reductions in office systolic blood pressure (20±15 mmHg) and diastolic blood pressure (10±13 mmHg) at 3 months.
  • Significant reductions in ambulatory systolic blood pressure (17.5±14.9 mmHg) and diastolic blood pressure (10.5±9.6 mmHg) at 6 months.
  • Improvements in left ventricular hypertrophy indices were noted.

Conclusions:

  • Renal denervation is a safe procedure for resistant essential hypertension.
  • The treatment leads to significant average blood pressure reduction.
  • Inter-individual variability in response was observed, consistent with other centers.
Abstract

Keywords:
Dénervation rénaleHypertension essentielleHypertension résistanteHypertrophie ventriculaire gaucheLeft ventricular hypertrophyNT-proBNPPrimary hypertensionRenal denervationResistant hypertension

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