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Updated: Apr 28, 2026

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager

Published on: February 2, 2019

Radiation-enhanced cell migration/invasion process: a review.

Coralie Moncharmont¹, Antonin Levy², Jean-Baptiste Guy³

¹Laboratoire de Radiobiologie Cellulaire et Moléculaire, EMR3738, Faculté de Médecine Lyon Sud, 69921 Oullins, France; Department of Radiotherapy, Institut de Cancérologie de la Lucien Neuwirth, St Priest en Jarez, France.

Critical Reviews in Oncology/Hematology

|June 9, 2014

Summary

This summary is machine-generated.

Photon radiation therapy can improve cancer survival, but some cancer cells survive and metastasize. This review explores how radiation enhances cancer cell invasion and potential therapeutic targets to improve antitumor effectiveness.

Keywords:

Carbon ion Cell invasion Epithelial–mesenchymal transition Radiation-enhanced Stroma

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Area of Science:

Oncology
Radiation Oncology
Cancer Metastasis Research

Background:

Photon radiation therapy is a primary cancer treatment, improving patient survival rates.
Despite its benefits, some cancer patients experience treatment resistance, leading to local recurrence or metastasis.
Metastasis involves complex cellular processes including migration, invasion, and the formation of secondary tumors.

Purpose of the Study:

To review the cellular mechanisms by which photon radiation enhances cancer cell invasion and metastasis.
To identify potential therapeutic targets for counteracting radiation-induced cancer cell invasiveness.
To explore strategies for improving the effectiveness of radiation therapy against aggressive cancer types.

Main Methods:

Literature review of studies investigating the effects of ionizing radiation on tumor cell behavior.
Analysis of cellular pathways implicated in radiation-induced migration, invasion, and epithelial-mesenchymal transition.
Examination of the tumor microenvironment's role in radiation-promoted metastasis.

Main Results:

Ionizing radiation can promote tumor cell migration and invasion through various mechanisms.
These mechanisms involve alterations in cell-cell and extracellular matrix interactions, protease secretion, and induction of epithelial-mesenchymal transition.
The tumor microenvironment plays a critical role in mediating these radiation-induced invasive phenotypes.

Conclusions:

Understanding the cellular pathways of photon-enhanced invasion is crucial for developing novel therapeutic strategies.
Targeting these pathways could enhance the efficacy of radiation therapy and combat treatment-resistant cancers.
Potential therapeutic approaches include specific inhibitors and advanced radiation modalities like carbon-ion therapy.