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Updated: Apr 28, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
[Management of vascular risk factors in patients older than 80]
Ricardo Gómez-Huelgas1, Manuel Martínez-Sellés2, Francesc Formiga3
1Sociedad Española de Medicina Interna (SEMI), España.
Insights
Cardiovascular disease prevention in patients over 80 requires tailored strategies due to heterogeneity and limited evidence. Comprehensive geriatric assessment is crucial for effective lifestyle and drug therapy decisions in the elderly.
Area of Science:
- Geriatric Medicine
- Cardiology
- Public Health
Background:
- The elderly population, particularly those over 80, is rapidly growing, presenting a significant challenge for healthcare systems.
- Cardiovascular diseases (CVDs) are a leading cause of mortality and morbidity in older adults, imposing a substantial disease burden.
- Existing cardiovascular risk assessment tools are inadequate for the very old, failing to account for factors like functional disability and dementia.
Framework:
- Recognizes the heterogeneity of the elderly population, including comorbidities and varying degrees of functional and cognitive impairment.
- Highlights age-associated physiological changes and polypharmacy as key considerations in this demographic.
- Emphasizes the need for individualized treatment plans based on risk/benefit assessments and comprehensive geriatric evaluations.
Implementation:
- Proposes clinical practice guidelines for primary and secondary cardiovascular prevention in individuals over 80.
- Offers recommendations for lifestyle modifications relevant to cardiovascular health in the elderly.
- Provides guidance on pharmacotherapy, stressing the importance of a risk/benefit analysis for drug use in older patients.
Implications:
- Aims to improve cardiovascular disease prevention strategies for the rapidly expanding elderly population.
- Supports evidence-based clinical decision-making for managing cardiovascular risk factors in very old individuals.
- Facilitates a more personalized and effective approach to geriatric cardiovascular care, addressing unique patient needs.
Abstract:
The number of patients older than 80 years is steadily increasing and it represents the main basis for increasing population figures in developed countries. Cardiovascular diseases are the leading causes of mortality and disability causes result in a huge burden of disease in elderly people. However, available scientific evidence to support decision-making on cardiovascular prevention in elderly patients is scarce. Currently available risk assessment scales cannot be applied to elderly people. They are focused on cardiovascular mortality risk and do not provide information on factors with a proven prognostic value in the very old (functioning disability, dementia). Elderly people are a highly heterogeneous population, with a variety of co-morbidities, as well as several functional and cognitive impairment degrees. Furthermore, aging-associated physiological changes and common use of multiple drugs result in an increased risk of adverse drug reactions. Thus, drug use should always be based on a risk/benefit assessment in the elderly. Therefore, therapeutic decision-making in the very old must be an individually tailored and based on an appropriate clinical judgement and a comprehensive geriatric assessment. The current consensus report aims to present a proposal for clinical practices in the primary and secondary cardiovascular prevention in the very old and to provide a number of recommendations on lifestyle changes and drug therapy for the management of major cardiovascular risk factors.
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