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Alveolar bone changes in experimentally induced prediabetes and diabetes
G Genaday1, A A Garfunkel, A M Cohen
1Tel Aviv University.
Israel Journal of Dental Sciences
|October 1, 1989
Summary
Diabetes and prediabetes significantly cause alveolar bone resorption, even in genetically predisposed rats. This bone loss is a noninflammatory degeneration needing more study.
Area of Science:
- Oral biology
- Endocrinology
- Pathology
Background:
- Alveolar bone resorption is linked to local and systemic factors.
- Diabetes mellitus is a potential systemic factor contributing to alveolar bone resorption.
Purpose of the Study:
- To investigate alveolar bone resorption in diabetic and prediabetic rat models.
- To determine if a genetic predisposition to diabetes causes bone loss.
Main Methods:
- Utilized rat models diagnosed with diabetes and prediabetes.
- Quantified alveolar bone resorption directly on jaw specimens.
Main Results:
- Significant differences in alveolar bone resorption were observed between diabetic, prediabetic, and control rats.
- Alveolar bone resorption occurred in rats with only a genetic predisposition to diabetes.
Conclusions:
- Diabetes and prediabetes are associated with significant alveolar bone resorption.
- Bone loss in these models represents a noninflammatory atrophic degeneration requiring further research.