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Related Concept Videos

Blood Types02:20

Blood Types

18.1K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
18.1K
Blood Typing01:10

Blood Typing

5.9K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
5.9K
The ABO Blood Group01:12

The ABO Blood Group

8.5K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
8.5K
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

12.8K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
12.8K
Rh Blood Group01:19

Rh Blood Group

4.3K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
4.3K

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Related Experiment Video

Updated: Apr 28, 2026

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
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Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray

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[ABO blood group genotyping based on amplification refractory mutation system].

Chao Zhang1, Juanli Zhu2, Jiangcun Yang3

  • 1College of Life Sciences, Northwest University, Xi'an 710069, China.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology
|June 10, 2014
PubMed
Summary

A new amplification refractory mutation system (ARMS) method accurately genotypes ABO blood groups. This cost-effective approach provides reliable ABO genotyping for clinical applications.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Clinical Diagnostics

Context:

  • Accurate ABO blood group genotyping is crucial for transfusion medicine and disease association studies.
  • Existing methods for ABO genotyping can be time-consuming or expensive.
  • There is a need for a rapid, cost-effective, and reliable genotyping method.

Purpose:

  • To develop and validate a novel amplification refractory mutation system (ARMS) method for ABO genotyping.
  • To assess the accuracy and efficiency of the ARMS method compared to established techniques.

Summary:

  • Six pairs of primers were designed for the amplification refractory mutation system (ARMS).
  • Peripheral blood DNA from 30 Chinese Han individuals was genotyped using ARMS.
  • ARMS results demonstrated perfect concordance with serological methods and DNA sequencing.

Impact:

  • The developed ARMS method accurately and rapidly detects 28 kinds of ABO genotypes.
  • This technique offers a new, reliable approach for ABO genotyping in clinical practice.
  • The method's cost-effectiveness and speed enhance its applicability in routine diagnostics.