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How can bioactive glasses be useful in ocular surgery?

Francesco Baino1

  • 1Institute of Materials Physics and Engineering, Applied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Torino, Italy.

Journal of Biomedical Materials Research. Part A
|June 10, 2014
PubMed
Summary

Bioactive glasses (BGs) show promise in ophthalmology for tissue regeneration. This review explores their potential in ocular surgery, including orbital repair and artificial corneas, highlighting future research directions.

Keywords:
angiogenesisartificial corneabioactive glasseye orbittissue integration

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Area of Science:

  • Biomaterials Science
  • Ophthalmology
  • Regenerative Medicine

Background:

  • Bioactive glasses (BGs) are bioceramics known for tissue bonding and regeneration, widely used in orthopedics and dentistry.
  • Historically, glass has been used in optics, with early intraocular implants documented since the 1700s.
  • Limited research exists on BGs in ophthalmology despite their potential.

Purpose of the Study:

  • To provide a comprehensive review of bioactive glass-based implants in ocular surgery.
  • To outline the strengths and limitations of current BG devices for ophthalmic applications.
  • To identify promising research avenues for BGs in ophthalmology, leveraging tissue engineering and regenerative medicine.

Main Methods:

  • Literature review of bioactive glass applications in ocular surgery.
  • Analysis of existing ophthalmic devices utilizing bioactive glasses.
  • Exploration of recent advancements in tissue engineering and regenerative medicine relevant to BGs.

Main Results:

  • Bioactive glasses show potential benefits for synthetic grafts in orbital bone repair.
  • BGs may enhance orbital implants for ocular globe replacement.
  • Evidence suggests BGs could improve keratoprostheses (artificial cornea) performance.

Conclusions:

  • Bioactive glasses offer significant potential for advancing ocular surgery and patient outcomes.
  • Further research is needed to overcome current limitations and fully realize BG applications in ophthalmology.
  • Integrating BGs with tissue engineering principles can drive innovation in regenerative ophthalmology.