Related Experiment Video
Updated: Apr 28, 2026
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Diffusion restriction in a non-enhancing metastatic brain tumor treated with bevacizumab - recurrent tumor or
Lakshmanan Sivasundaram1, Saman Hazany1, Naveed Wagle2
1Division of Neuroradiology, Department of Radiology, Keck School of Medicine of USC.
Abstract:
A 38-year-old female with metastatic brain cancer developed non-enhancing, diffusion restricted lesions following bevacizumab treatment. From our review of the literature, this is the first reported case of this type of lesion. Clinicians should be wary of these lesions, as they can represent either tumor progression or necrosis/effects of chronic hypoxia from anti-angiogenic therapy. Further investigation is necessary to determine the biological mechanism and clinical significance of this type of imaging appearance.
