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Enterovirus infections are associated with white matter damage in neonates

Tai Wu1, Xiao-Ping Fan, Wei-Yan Wang

  • 1Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Journal of Paediatrics and Child Health
|June 10, 2014
PubMed

Insights

Enterovirus infections in newborns can lead to severe central nervous system disease. Neuroimaging, including cranial ultrasonography and MRI, is crucial for diagnosis and management of these neonatal enterovirus infections.

Area of Science:

  • Neonatal Neurology
  • Infectious Diseases
  • Pediatric Radiology

Background:

  • Enteroviruses are a common cause of neonatal infections.
  • Central nervous system involvement can lead to significant morbidity and mortality in neonates.
  • Early diagnosis and management are critical for improving outcomes.

Purpose of the Study:

  • To investigate the neuroimaging findings in neonatal infants with enterovirus infections.
  • To correlate imaging findings with clinical presentation and neurodevelopmental outcomes.

Main Methods:

  • Retrospective analysis of 12 neonatal infants diagnosed with enterovirus encephalitis.
  • Review of clinical data, cranial ultrasonography (cUS), and magnetic resonance imaging (MRI) findings.
  • Assessment of neurodevelopmental outcomes at 18 months follow-up.

Main Results:

  • All 12 infants showed white matter changes on neonatal MRI.
  • One preterm infant had periventricular echogenicity on cUS.
  • Outcomes varied, with 2 infants developing cerebral palsy and 10 having normal neurodevelopment.

Conclusions:

  • Enterovirus infection can result in severe central nervous system disease in neonates.
  • Neuroimaging studies (cUS and MRI) are informative for diagnosing and managing these infections.
  • Neuroimaging should be an integral part of the care for infants with enteroviruses.
Abstract

Keywords:
enterovirus infectionneonatewhite matter damage

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