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Silk-based biomaterials for sustained drug delivery.

Tuna Yucel1, Michael L Lovett1, David L Kaplan2

  • 1Tufts University, Department of Biomedical Engineering, Medford, MA 02155, USA; Ekteino Laboratories, New York, NY 10022, USA.

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|June 10, 2014
PubMed
Summary

Silk offers a unique platform for sustained drug delivery, utilizing its biocompatibility and controllable degradation. This versatile material enables advanced formulations for various drugs, addressing limitations of current technologies.

Keywords:
BiocompatibilityBiodegradationBiologicsDrugsMechanismsProcessing

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Chemistry

Background:

  • Silk possesses unique properties like biocompatibility, controllable degradation, and mechanical strength, making it suitable for drug delivery.
  • Current drug delivery technologies face limitations that silk-based systems can potentially overcome.
  • Silk's tunable structural hierarchy and modification options allow for tailored pharmaceutical outcomes.

Purpose of the Study:

  • To discuss the unique aspects of silk technology as a sustained drug delivery platform.
  • To highlight the current state-of-the-art in silk-based drug delivery.
  • To propose a potential development pathway for silk-based sustained delivery products.

Main Methods:

  • Review of silk's properties relevant to drug delivery (biocompatibility, degradation, mechanical properties).
  • Analysis of silk's structural hierarchy and modification capabilities for drug formulation.
  • Examination of release mechanisms (diffusion and degradation) for sustained drug release.

Main Results:

  • Silk enables sustained drug delivery for small to macromolecular drugs without chemical cross-linkers.
  • Silk formulations leverage structural hierarchy and self-assembly for targeted pharmaceutical outcomes.
  • Near-zero order sustained release is achievable by manipulating silk-drug interactions.

Conclusions:

  • Silk technology presents a promising, versatile platform for advanced sustained drug delivery.
  • Increasing industrial interest and products in development highlight silk's potential.
  • Silk offers a viable alternative to existing degradable sustained delivery technologies.