Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

13.6K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
13.6K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

14.3K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.3K
T Cell Types and Functions01:24

T Cell Types and Functions

3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Repurposing licensed viral vaccines as anti-cancer therapeutics: Turning cold tumors hot.

Human vaccines & immunotherapeutics·2026
Same author

CD40 Agonism in Pancreatic Ductal Adenocarcinoma: Expression, Biology, and Therapeutic Targeting.

Cancers·2026
Same author

From measurement to meaning: Re-examining merit in medical school selection.

Medical teacher·2026
Same author

The effect of feedback on the diagnostic process of physicians at the emergency department: a systematic review.

European journal of emergency medicine : official journal of the European Society for Emergency Medicine·2026
Same author

Comparison of cognitive workload between very short answer questions and multiple-choice questions: an eye-tracking experiment.

Medical education online·2026
Same author

What is the best curriculum timing for an educational podcast aiming to improve medical students' attitudes towards physician-pharmacist collaboration: a pre-post study.

BMC medical education·2025

Related Experiment Video

Updated: Apr 28, 2026

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
06:12

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

3.0K

BDCA3(+)CLEC9A(+) human dendritic cell function and development.

Evelyn van der Aa1, Nadine van Montfoort1, Andrea M Woltman1

  • 1Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.

Seminars in Cell & Developmental Biology
|June 10, 2014
PubMed
Summary

Newly identified BDCA3(+)CLEC9A(+) dendritic cells (DC) are potent antigen-presenting cells (APC). These cells are crucial for initiating anti-viral and anti-tumor immune responses, offering potential for immunotherapy.

Keywords:
BDCA3Cross-presentationDendritic cell subsetHumanIFNλImmune regulation

More Related Videos

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

10.3K
An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

14.9K

Related Experiment Videos

Last Updated: Apr 28, 2026

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
06:12

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

3.0K
Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

10.3K
An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

14.9K

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Dendritic cells (DC) are key antigen-presenting cells (APC) orchestrating immune responses.
  • Human DC comprise diverse subsets with distinct functions.
  • BDCA3(+)CLEC9A(+) DC represent a newly identified, rare human DC subset found in blood and tissues.

Purpose of the Study:

  • To review the phenotypic, functional, and developmental characteristics of BDCA3(+)CLEC9A(+) DC.
  • To compare BDCA3(+)CLEC9A(+) DC with mouse equivalents (CD8α(+) DC, CD103(+) DC) and other human DC subsets.
  • To highlight the potential of BDCA3(+)CLEC9A(+) DC in anti-viral and anti-tumor immunity and immunotherapy.

Main Methods:

  • Review of existing literature.
  • Gene expression profiling.
  • Phenotypic and functional analysis of dendritic cell subsets.

Main Results:

  • BDCA3(+)CLEC9A(+) DC are a distinct human DC subset with potent antigen-presenting capabilities.
  • This subset exhibits specialized functions critical for anti-viral and anti-tumor immunity.
  • Comparison with mouse DC subsets (CD8α(+) DC, CD103(+) DC) reveals conserved and divergent characteristics.

Conclusions:

  • BDCA3(+)CLEC9A(+) DC play a significant role in initiating adaptive immune responses.
  • Their unique functional properties suggest major importance in anti-viral and anti-tumor immunity.
  • Further research into their development and molecular mechanisms could unlock their therapeutic potential in immunotherapy.