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Updated: Apr 28, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
[MRI and CT in the diagnosis of epilepsy]
Abstract:
MRI and CT are important for the diagnosis and treatment of epilepsy. Diffusion-weighted images are particularly useful for detecting early changes in the brain. In this article, I reviewed radiological findings associated with seizures (reduced diffusion and swelling of hippocampus and cortex, and a reversible splenial lesion), and lesions causing epilepsy and seizures, such as congenital abnormality of the brain (holoprosencephaly, hemimegalencephaly, lissencephaly, heterotopia, polymicrogyria, schizencephaly, and focal cortical dysplasia), neurocutaneous syndromes (tuberous sclerosis and Sturge-Weber syndrome), vascular disorders (moyamoya disease/syndrome and cavernous angioma), and encephalitis/encephalopathy (herpes encephalitis, anti-NMDA receptor encephalitis, acute necrotizing encephalopathy of childhood, and acute encephalopathy with biphasic seizures and late reduced diffusion).
Insights
Radiology, including MRI and CT scans, aids epilepsy diagnosis by identifying brain changes like hippocampal swelling and reversible lesions. This review covers imaging findings for seizures and various underlying causes.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Epilepsy diagnosis and treatment rely heavily on neuroimaging techniques.
- Diffusion-weighted imaging (DWI) is crucial for detecting early cerebral alterations.
Purpose of the Study:
- To review key radiological findings in epilepsy.
- To correlate imaging findings with seizure activity and underlying etiologies.
Main Methods:
- Review of radiological findings in epilepsy.
- Analysis of imaging in congenital brain abnormalities, neurocutaneous syndromes, vascular disorders, and encephalitis/encephalopathy.
Main Results:
- Identified seizure-associated findings: reduced diffusion, hippocampal/cortical swelling, reversible splenial lesions.
- Cataloged imaging features of epilepsy-causing lesions: congenital abnormalities (e.g., focal cortical dysplasia), neurocutaneous syndromes (e.g., tuberous sclerosis), vascular disorders (e.g., moyamoya), and encephalitis (e.g., herpes encephalitis).
Conclusions:
- Radiological findings are vital for diagnosing epilepsy and identifying its causes.
- Advanced imaging techniques like DWI enhance the detection of subtle and early neuropathological changes associated with seizures.
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