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[ASK1-MAP kinase signaling pathway as a therapeutic target for human diseases]

Takao Fujisawa, Hidenori Ichijo

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |June 11, 2014
    PubMed

    Insights

    Apoptosis signal-regulating kinase 1 (ASK1) is a stress-activated kinase crucial for cellular responses. This review explores ASK1

    Area of Science:

    • Molecular Biology
    • Cell Signaling
    • Biochemistry

    Context:

    • Apoptosis signal-regulating kinase 1 (ASK1), a member of the MAPK kinase kinase family, is activated by cellular stresses like ROS, TNF-alpha, LPS, and ER stress.
    • ASK1 plays critical roles in cellular processes including apoptosis, differentiation, and inflammation.
    • Dysregulation of ASK1-MAPK signaling is implicated in various human diseases.

    Purpose:

    • To provide a comprehensive overview of the current understanding of ASK1.
    • To highlight the significance of the ASK1-MAPK signaling pathway in human diseases.
    • To evaluate ASK1 as a potential therapeutic target for treating human diseases.

    Summary:

    • ASK1 is a key kinase activated by diverse cellular stresses.
    • Its signaling pathway is integral to fundamental cellular functions.
    • Recent research underscores ASK1's involvement in stress-response-related human pathologies.

    Impact:

    • Understanding ASK1's role in stress responses offers insights into disease mechanisms.
    • Identifying ASK1 as a therapeutic target opens avenues for novel treatment strategies.
    • This review consolidates current knowledge, guiding future research in ASK1-related diseases.

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