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The structure and function of the int-2 oncogene
1Department of Viral Carcinogenesis and Imperial Cancer Research Fund Laboratories, London, U.K.
Abstract:
The classification of int-2 as a growth factor is based primarily on the similarities between the predicted amino acid sequence and that of basic fibroblast growth factor (bFGF), as well as other members of this expanding family of related proteins. In this review, we summarise the background to the identification of int-2 as a proto-oncogene in virally induced mouse mammary tumours and describe key features of the structure and expression of both the mouse and human homologues. The normal sites of int-2 expression include specific embryonic cell types suggesting multiple inductive or morphogenetic roles. Recent progress in the characterisation of the int-2 product will be discussed in relation to the similarities and differences between int-2 and other FGFs.
Insights
The int-2 proto-oncogene, similar to basic fibroblast growth factor (bFGF), plays roles in embryonic development. Its classification as a growth factor highlights its potential in cell growth and differentiation research.
Area of Science:
- Oncology
- Developmental Biology
- Molecular Biology
Background:
- The int-2 gene was identified as a proto-oncogene in mouse mammary tumors.
- Its predicted amino acid sequence shares similarities with basic fibroblast growth factor (bFGF) and other FGF family members.
Purpose of the Study:
- To review the identification and characteristics of the int-2 proto-oncogene.
- To discuss the structure, expression, and potential roles of int-2 in mammalian development.
Main Methods:
- Sequence homology analysis comparing int-2 to known growth factors.
- Review of existing literature on int-2 gene identification and expression patterns.
Main Results:
- int-2 exhibits structural and sequence similarities to the FGF family.
- Normal expression sites in embryonic cells suggest roles in morphogenesis and induction.
- Comparison of mouse and human int-2 homologues.
Conclusions:
- int-2 functions as a growth factor with potential roles in embryonic development.
- Further characterization of the int-2 product is needed to understand its similarities and differences with other FGFs.