Clinical and pharmacological approach to the diagnosis of paranoid schizophrenia

The aim of the study was finding out the correlations between some clinical and biological variables in paranoid schizophrenia. The group of 16 patients with paranoid schizophrenia, chosen in careful diagnostic procedure was treated with perazine during 4 weeks time. Before and during the treatment, the following parameters: psychopathology, serum perazine and prolactin concentration, dopamine-beta-hydroxylase activity and simple reaction time were measured. We found changes of those parameters caused by the treatment. The simple reaction time retardation was side-dependent before the treatment and not side-dependent after the treatment.