Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Studies on circulation rate and flow model for external loop bioreactor.

K Liu1, X Z Jiang, B Z Li

  • 1Beijing Research Institute for Nutritional Resources.

Chinese Journal of Biotechnology
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A multicenter retrospective clinical study of a simplified comprehensive geriatric assessment system in elderly patients with diffuse large B-cell lymphoma].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2025
Same author

[The distribution and biomechanical characteristics of foot deformities among elderly diabetic patients based on community screening].

Zhonghua yi xue za zhi·2024
Same author

[Application of trajectory models in longitudinal data analysis with single-outcome measurements].

Zhonghua nei ke za zhi·2024
Same author

[The efficacy and safety profile of ixazomib/lenalidomide/dexamethasone in relapsed/refractory multiple myeloma: a multicenter real-world study in China].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2021
Same author

[Surgery treatment and prognosis analysis of 129 small cell carcinoma of the esophagogastric junction].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2021
Same author

Identification of peroxiredoxin 6 as a potential lung-adenocarcinoma biomarker for predicting chemotherapy response by proteomic analysis.

Journal of biological regulators and homeostatic agents·2021
Same journal

Detection and nucleotide analysis of RNA5 of beet necrotic yellow vein virus isolated in China.

Chinese journal of biotechnology·2000
Same journal

Continuous ethanol fermentation using the fusion strain SPSC (I) flocs: floc size distribution, cell growth, and ethanol fermentation kinetics.

Chinese journal of biotechnology·2000
Same journal

Study on rt-PA production by recombinant CHO cells immobilized with a porous microcarrier.

Chinese journal of biotechnology·2000
Same journal

Optimization of conditions for safflower cell culture and accumulation of cellicolous product tocopherols.

Chinese journal of biotechnology·2000
Same journal

Gene fusion and expression of heat-labile and heat-stable enterotoxins of enterotoxigenic Escherichia coli.

Chinese journal of biotechnology·2000
Same journal

Expression of rainbow trout growth hormone cDNA in Saccharomyces cerevisiae.

Chinese journal of biotechnology·2000
See all related articles

This study presents a new electrical conductivity tracking system to measure circulation rate in external loop bioreactors. This method aids in developing a bioreactor flow model for improved scale-up.

Area of Science:

  • Biochemical Engineering
  • Fluid Dynamics

Background:

  • External loop bioreactors are crucial for bioprocesses.
  • Accurate measurement of circulation rate is essential for bioreactor scale-up and performance optimization.
  • Existing methods for measuring circulation resistance in bioreactors present challenges.

Purpose of the Study:

  • To develop and validate a novel method for measuring circulation rate in external loop bioreactors.
  • To obtain a bioreactor flow model by studying circulation rate variations.
  • To derive a theoretical formula for circulation rate to facilitate bioreactor scale-up.

Main Methods:

  • Experiments were conducted in an external loop bioreactor (250 mm diameter, 4500 mm height).
  • An electrical conductivity tracking system was developed to measure circulation rate (Um).

Related Experiment Videos

  • Circulation rate was studied across a range of superficial gas velocities (UG = 0-24.9 cm/s).

    • Main Results:

    • A bioreactor flow model was successfully obtained.
    • The developed electrical conductivity tracking system effectively measured circulation rate and circulation resistance.
    • A theoretical formula for circulation rate (Um) was derived.

    Conclusions:

    • The novel electrical conductivity tracking system provides an effective solution for measuring circulation rate and resistance in bioreactors.
    • The derived theoretical formula and obtained flow model are valuable for the scale-up of external loop bioreactors.
    • This work contributes to the optimization and reliable scale-up of bioprocesses utilizing external loop bioreactors.