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Updated: Apr 28, 2026

Quantifying the Antifungal Activity of Peptides Against Candida albicans
Published on: January 13, 2023
Structure-activity relationship study of the plant-derived decapeptide OSIP108 inhibiting Candida albicans biofilm
Nicolas Delattin1, Katrijn De Brucker1, David J Craik2
1Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
Abstract:
We performed a structure-activity relationship study of the antibiofilm plant-derived decapeptide OSIP108. Introduction of positively charged amino acids R, H, and K resulted in an up-to-5-fold-increased antibiofilm activity against Candida albicans compared to native OSIP108, whereas replacement of R9 resulted in complete abolishment of its antibiofilm activity. By combining the most promising amino acid substitutions, we found that the double-substituted OSIP108 analogue Q6R/G7K had an 8-fold-increased antibiofilm activity.
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