Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

8.4K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.4K
Visual Agnosia01:12

Visual Agnosia

2.0K
Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round...
2.0K
Glaucoma: Overview01:25

Glaucoma: Overview

1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Vision01:24

Vision

48.5K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
48.5K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply to: A Lethal Progressive Neuroinflammation Disguised as MOGAD Revealing a Final Diagnosis of Griscelli Syndrome: Regarding: MOGAD is the Most Common Cause of Isolated Optic Neuritis in Children.

Annals of clinical and translational neurology·2026
Same author

Investigation of the relationship between the cephalic index and the tentorium cerebelli: A retrospective study.

Medicine·2026
Same author

Deciphering the Genomic Landscape of Renal Cell Carcinoma Brain Metastases.

bioRxiv : the preprint server for biology·2026
Same author

Orbital chordoid meningioma: a rare entity with an aggressive clinical course.

Orbit (Amsterdam, Netherlands)·2026
Same author

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children.

Annals of clinical and translational neurology·2026
Same author

Impact of DNA Methylation Profiling on Central Nervous System Tumor Diagnosis and Management: A Pediatric Cohort Study from Türkiye.

Turkish neurosurgery·2026
Same journal

Efficacy and safety of different intraocular therapies for non-infectious uveitis: A network meta-analysis.

Survey of ophthalmology·2026
Same journal

Macular telangiectasia masqueraders.

Survey of ophthalmology·2026
Same journal

Utilization of anterior segment optical coherence tomography in childhood glaucoma: A systematic review.

Survey of ophthalmology·2026
Same journal

Peripapillary pachychoroid syndrome: Clinical and imaging features, diagnostic differentiation and therapeutic strategies.

Survey of ophthalmology·2026
Same journal

Prognostic factors and postoperative outcomes in pediatric cataract patients: A systematic review and meta-analysis.

Survey of ophthalmology·2026
Same journal

Predicting the progression of proliferative diabetic retinopathy: Pathophysiology, imaging phenotypes, and determinants of disease persistence despite therapy.

Survey of ophthalmology·2026
See all related articles

Related Experiment Video

Updated: Apr 28, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

7.7K

Acute visual loss: just the beginning?

Ayse Ilksen Colpak1, Ilkay Isikay2, Melike Mut2

  • 1Institute of Neurological Sciences and Department of Neurology, Neuro-ophthalmology Unit, Hacettepe University, Sihhiye, Ankara, Turkey.

Survey of Ophthalmology
|June 11, 2014
PubMed
Summary
This summary is machine-generated.

A rare case of glioblastoma mimicking optic neuritis, initially suspected to be Lyme disease, presented with rapid visual loss and neurological deficits, leading to a fatal outcome.

Keywords:
acute visual lossglioblastomaglioblastoma multiformemalignant optic glioma of adulthood (MOGA)ophthalmoplegiaoptic neuropathyretinal artery occlusion

More Related Videos

Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss
07:12

Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss

Published on: April 11, 2025

1.0K
Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients
07:06

Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients

Published on: March 29, 2022

3.2K

Related Experiment Videos

Last Updated: Apr 28, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

7.7K
Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss
07:12

Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss

Published on: April 11, 2025

1.0K
Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients
07:06

Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients

Published on: March 29, 2022

3.2K

Area of Science:

  • Neuro-oncology
  • Ophthalmology
  • Infectious Disease

Background:

  • Optic nerve inflammation and visual disturbances can be caused by various conditions, including infections and primary tumors.
  • Borrelia burgdorferi infection (Lyme disease) can present with neurological manifestations, including optic nerve involvement.

Observation:

  • A 47-year-old male experienced sudden left-sided visual loss, optic disc edema, and retinal ischemia.
  • Initial MRI showed a thickened, enhancing left optic nerve, with positive Borrelia burgdorferi IgM.
  • Neurological progression included left-sided numbness and weakness, with MRI revealing extensive enhancing lesions along the visual pathways.

Findings:

  • Stereotactic biopsy confirmed glioblastoma in the right pulvinar lesion.
  • The tumor exhibited rapid progression, extending from the optic nerve to bilateral visual pathways.

Implications:

  • This case highlights the importance of considering primary CNS tumors in the differential diagnosis of optic nerve inflammation, even with positive serology for infectious agents.
  • Glioblastoma can present with atypical initial symptoms mimicking inflammatory or infectious optic neuropathies.
  • Rapid progression and extensive involvement of visual pathways underscore the aggressive nature of this glioblastoma presentation.