Immunisations in Crohn's disease: who? why? what? when?
1Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Portugal; Gastroenterology Department, Faculty of Medicine, Centro Hospitalar S. João, Porto, Portugal; MedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal.
Best Practice & Research. Clinical Gastroenterology
|June 11, 2014
Summary
Vaccination is crucial for Crohn's disease (CD) patients to prevent infections, especially during immunosuppression. This review highlights essential vaccines for CD patients, travelers, and their close contacts.
Area of Science:
- Immunology
- Gastroenterology
- Public Health
Background:
- Immunosuppressive therapy in Crohn's disease (CD) patients significantly elevates infection risk.
- Low vaccination rates in CD patients stem from misinformation regarding vaccine safety and efficacy.
- Vaccines and immunoglobulins are vital for preventing infectious diseases and reducing mortality.
Purpose of the Study:
- To emphasize the critical need for vaccination in Crohn's disease (CD) patients.
- To outline recommended vaccines for CD patients at diagnosis and throughout their disease course, including during immunosuppression.
- To address vaccination considerations for CD patients who travel and for their healthy household members.
Main Methods:
- Review of current literature on vaccine efficacy and safety in inflammatory bowel disease.
- Analysis of vaccination guidelines relevant to immunocompromised individuals.
- Discussion of specific vaccine recommendations for CD patients.
Main Results:
- Identified key vaccines including measles, varicella, zoster, papillomavirus, shingles, pneumococcal, influenza, and hepatitis A and B.
- Highlighted the importance of tailored vaccination strategies considering disease activity and immunosuppressive status.
- Emphasized the need for updated information to improve vaccination uptake in CD patients.
Conclusions:
- Vaccination is a fundamental preventive measure for Crohn's disease patients to mitigate infection risks.
- Comprehensive vaccination strategies are necessary for CD patients, encompassing routine care, travel, and household contacts.
- Addressing misinformation and ensuring access to vaccines are crucial for improving the health outcomes of CD patients.
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