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Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease V: Surgical Management01:21

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Related Experiment Video

Updated: Apr 28, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

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When can we cure Crohn's?

Gerassimos J Mantzaris1

  • 1Department of Gastroenterology, Evangelismos Hospital, 45-47 Ypsilantou Street, 10676 Athens, Greece.

Best Practice & Research. Clinical Gastroenterology
|June 11, 2014
PubMed
Summary
This summary is machine-generated.

Crohn's disease (CD) is a chronic inflammatory condition. Future treatments may integrate research on all disease components for a potential cure.

Keywords:
AminosalicylatesBiologicsCorticosteroidsCrohn's diseaseEnvironmental factorsFeacal microbiota transplantationGeneticsGut microbiotaImmunosuppressantsMucosal immunity

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Area of Science:

  • Gastroenterology and immunology.

Background:

  • Crohn's disease (CD) is a chronic, idiopathic inflammatory disorder affecting the gastrointestinal tract and potentially other organs.
  • CD pathogenesis involves complex interactions between environmental factors, gut microbiota, host genetics, and the immune system.

Purpose of the Study:

  • To review the current understanding of Crohn's disease pathogenesis.
  • To highlight the evolution of therapeutic strategies, including biologic agents.
  • To propose a holistic approach for future research towards a potential cure for CD.

Main Methods:

  • Review of existing research on Crohn's disease pathogenesis.
  • Analysis of the impact of recent therapeutic advancements, particularly biologic agents.
  • Discussion of the need for integrated research across multiple pathogenetic pathways.

Main Results:

  • Significant advancements in treating CD have been made with biologic agents, improving patient outcomes.
  • Despite progress, a cure for Crohn's disease remains elusive.

Conclusions:

  • A comprehensive, integrated research approach targeting multiple pathogenetic pathways is crucial for developing novel therapies.
  • This holistic strategy may unravel the complexities of CD and lead to a cure.