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Updated: Apr 28, 2026

Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer
Published on: September 24, 2021
Effect of hypoxia on porphyrin metabolism in bone marrow mesenchymal stem cells
A G Poleshko1, E S Lobanok, I D Volotovskii
1Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus, Minsk, Belarus, Renovacio888@yandex.ru.
Abstract:
Under hypoxic conditions, aminolevulinic acid-induced accumulation of porphyrin pigments and increase in heme content was observed in bone marrow mesenchymal stem cells. The expression of transferrin receptor CD71 responsible for Fe(2+) transport into the cell was also enhanced. Blockade of porphyrin-transporting protein ABCG2 with fumitremorgin C under conditions of normoxia and hypoxia induced accumulation of porphyrin pigments; in hypoxia, these changes were more pronounced.
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