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Updated: Apr 28, 2026

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

Antimicrobial megaprostheses supported with iodine.

Toshiharu Shirai¹, Hiroyuki Tsuchiya², Hideji Nishida³

¹Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.

Journal of Biomaterials Applications

|June 11, 2014

Summary

Iodine-coated titanium megaprostheses effectively prevented and treated deep infections in orthopedic surgery patients. This innovative implant coating showed no adverse effects, promoting bone ingrowth and successful outcomes.

Keywords:

Iodine antimicrobial implant infection megaprosthesis

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Area of Science:

Orthopedic Surgery
Biomaterials Science
Infectious Disease Management

Background:

Deep implant infections are a significant complication in orthopedic surgery.
Titanium implants are widely used, but infection remains a challenge.
Iodine coating offers potential antibacterial properties for orthopedic implants.

Purpose of the Study:

To evaluate the safety and efficacy of iodine-coated titanium megaprostheses.
To assess the antibacterial effects of iodine coating in preventing and treating infections.
To investigate potential systemic effects and implant integration.

Main Methods:

Clinical trial involving 47 patients with bone tumors or arthritis receiving iodine-coated megaprostheses.
Megaprostheses used for infection prevention (21 patients) and treatment (26 patients).
Follow-up included clinical assessment, infection markers (WBC, CRP), and thyroid hormone levels.

Main Results:

High success rate in preventing infection (20/21 patients) and treating existing infections (26/26 patients).
No implant loosening or adverse systemic effects (thyroid function) observed.
Excellent bone ingrowth and ongrowth demonstrated around the implants.

Conclusions:

Iodine-supported titanium megaprostheses are effective for preventing and treating infections in large bone defects.
The coating demonstrates a favorable safety profile with no cytotoxicity.
This technology shows promise for improving outcomes in high-risk orthopedic procedures.