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Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
Published on: May 10, 2024
miRNA polymorphisms and risk of gastric cancer in Asian population
Hai-Bing Hua1, Ting-Ting Yan1, Qing-Min Sun1
1Hai-Bing Hua, Department of Gastroenterology, Jiangyin Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Jiangyin 214400, Jiangsu Province, China.
Abstract:
miRNAs are endogenous 19- to 25-nt noncoding RNAs that can negatively regulate gene expression by directly cleaving target mRNA or by inhibiting its translation. Recent studies have revealed that miRNA plays a significant role in gastric cancer development either as a tumor suppressor gene or oncogene. miRNA-single-nucleotide polymorphisms (SNPs), as a novel class of functional SNPs/polymorphisms, have been identified as candidate biomarkers for gastric cancer susceptibility. On the basis of recent data, the present review summarizes current knowledge of the functional effects of miRNA-SNPs and their importance as candidate gastric cancer biomarkers. Additionally, this review also includes a meta-analysis of the most frequently studied miRNA-SNPs in gastric cancer.
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