BMP-functionalised coatings to promote osteogenesis for orthopaedic implants

Area of Science:

• Biomaterials Science
• Orthopaedic Surgery
• Tissue Engineering

Background:

• Bone integrity loss impacts patient aesthetics and mobility, necessitating effective treatments.
• Current orthopaedic implants (allografts, xenografts, synthetics) often lack osteoinductivity, hindering natural bone formation.
• Osteoinductive functionalisation is crucial for promoting local osteogenesis and implant osseointegration.

Purpose of the Study:

• To review current knowledge on bone morphogenetic protein (BMP)-functionalised coatings for orthopaedic implants.
• To summarise recent advances in developing osteoinductive coatings.
• To highlight the effectiveness of BMP-functionalisation for enhancing implant performance.

Main Methods:

• Literature review of studies on BMP-functionalised coatings for orthopaedic implants.
• Analysis of strategies for functionalising implants with BMPs.
• Synthesis of findings on the efficacy of these coatings in promoting bone formation.

Main Results:

• BMP-functionalised coatings represent a simple and effective strategy for orthopaedic implants.
• These coatings enhance local osteogenesis and implant osseointegration.
• Significant advances have been made in the development and application of BMP coatings.

Conclusions:

• BMP-functionalised coatings are a promising approach to overcome the limitations of conventional orthopaedic implants.
• This strategy effectively promotes bone regeneration and improves implant integration.
• Further research and development in this area hold potential for improved patient outcomes.