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Colloidal particles containing labeling agents and cyclodextrins for theranostic applications.

Nadiah Zafar1, Hatem Fessi1, Abdelhamid Elaissari1

  • 1University of Lyon, F-69622 Lyon, France, University Lyon 1, Villeurbanne, CNRS, UMR 5007, LAGEP-CPE, 43 Bd. 11 Novembre 1918, Villeurbanne F-69622, France.

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Cyclodextrins (CDs) enhance theranostic agents by encapsulating hydrophobic drugs within their cavities. This review explores CD-based systems for improved drug loading, labeling, and controlled release in biomedical applications.

Keywords:
CyclodextrinsEncapsulation efficiencyPore control motifsRelease rateTheranostics

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Cyclodextrins (CDs) are biocompatible, sugar-based macrocycles with broad biomedical applications.
  • Recent research has focused on CD-particle conjugates for drug delivery systems.
  • Theranostic agents combine diagnostic and therapeutic capabilities.

Purpose of the Study:

  • To review cyclodextrin (CD)-based theranostic agents, focusing on systems combining CDs and colloidal particles.
  • To elucidate the key features and recent applications of these theranostic systems.
  • To highlight the role of CDs in enhancing theranostic properties.

Main Methods:

  • Literature review of cyclodextrin-based theranostic agents.
  • Discussion of fundamental theranostic approaches utilizing CD-colloidal particle conjugates.
  • Presentation of recent pertinent applications.

Main Results:

  • CDs enhance theranostic properties by providing apolar cavities for hydrophobic molecule encapsulation.
  • CDs improve particle loading capacity by hosting active molecules.
  • CDs are relevant for enhancing particle labeling and controlled drug release.

Conclusions:

  • CD-based theranostic agents offer significant potential in biomedical applications.
  • The combination of CDs with colloidal particles provides a versatile platform for theranostics.
  • Further development of these systems can lead to advanced drug delivery and diagnostic tools.