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Author Spotlight: Establishing a Practical and Cost-Effective Protocol for Corneal Sensitivity Testing in Clinical Settings
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Mechanical sensitivity of the human conjunctiva.

Maria Navascues-Cornago1, Carole Maldonado-Codina, Philip B Morgan

  • 1Eurolens Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom.

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|June 11, 2014
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Summary

The marginal conjunctiva is the most sensitive ocular region, surpassing the cornea and other conjunctival areas. Its sensitivity remains consistent throughout the day, unaffected by morning or evening measurements.

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Area of Science:

  • Ophthalmology
  • Ocular Surface Research
  • Sensory Physiology

Background:

  • Understanding the sensitivity of different ocular surface regions is crucial for diagnosing and managing various eye conditions.
  • Previous research has established varying sensitivity levels across the ocular surface, but detailed mapping of conjunctival regions and diurnal variations is less explored.

Purpose of the Study:

  • To map the mechanical sensitivity of the marginal and other conjunctival regions of the eye.
  • To investigate potential diurnal changes (morning vs. evening) in the sensitivity of these ocular surface areas.

Main Methods:

  • Mechanical sensitivity was assessed at eight ocular locations, including the cornea and conjunctiva (marginal, bulbar, tarsal), using a Cochet-Bonnet esthesiometer in 35 healthy subjects.
  • A subset of 11 participants underwent repeated sensitivity measurements after a 12-hour interval to assess diurnal variations.

Main Results:

  • The cornea exhibited the highest sensitivity, followed by the marginal conjunctiva, which was more sensitive than the bulbar and tarsal conjunctiva.
  • Temporal marginal conjunctiva was more sensitive than central, and upper tarsal conjunctiva was more sensitive than lower.
  • No significant differences in sensitivity were observed between morning and evening measurements for any ocular location.

Conclusions:

  • The marginal conjunctiva is the most sensitive among the conjunctival regions studied.
  • Ocular surface sensitivity, particularly in the marginal conjunctiva, does not significantly change between morning and evening.