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Some challenges with statistical inference in adaptive designs.

H M James Hung1, Sue-Jane Wang, Peiling Yang

  • 1a Division of Biometrics I , Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration , Silver Spring , Maryland , USA.

Journal of Biopharmaceutical Statistics
|June 11, 2014
PubMed
Summary
This summary is machine-generated.

Adaptive clinical trial designs, including adaptive statistical information and selection designs, present statistical challenges. This study identifies practical issues with existing methods for adaptive statistical information designs and highlights assessment difficulties for adaptive selection designs.

Failed At:

2026-06-19T13:37:09.475772+00:00

Keywords:
Adaptive selectionAdaptive statistical informationBiomarkerMarkerUnweighted Z statisticWeighted Z statistic

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