Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.7K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.7K
Seizures: Classification01:13

Seizures: Classification

2.5K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
2.5K
Seizures l: Introduction01:20

Seizures l: Introduction

36
Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
36
Overview of Synapses01:25

Overview of Synapses

10.9K
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
10.9K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

4.6K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.6K
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

1.2K
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ictal cardiac activity: Towards a wider, dynamical vista.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2017
Same author

Subcortical (thalamic) automated seizure detection: A new option for contingent therapy delivery.

Epilepsia·2015
Same author

Probability of detection of clinical seizures using heart rate changes.

Seizure·2015
Same author

The NeuroPace trial: missing knowledge and insights.

Epilepsia·2014
Same author

Recruitment responses do not localize electrodes to thalamus.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2014
Same author

Recruitment responses have no localizing value.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2014

Related Experiment Video

Updated: Apr 28, 2026

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems
06:28

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Published on: September 27, 2024

2.7K

Competition for neuronal processing time: a physiological seizure control mechanism?

Ivan Osorio1

  • 1University of Kansas Medical Center, Kansas City, KS, USA.

Epilepsy & Behavior : E&B
|June 11, 2014
PubMed
Summary

A novel cognitive test, the complex reaction time (CRT) test, may reduce seizure frequency and severity in epilepsy patients. This cognitive intervention shows promise for seizure control, warranting further investigation.

Keywords:
Cognitive seizure controlCompetitionComplex reaction timeContingentNeuronal processing timeUnconditioned

More Related Videos

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

8.4K
Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
10:24

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

16.6K

Related Experiment Videos

Last Updated: Apr 28, 2026

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems
06:28

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Published on: September 27, 2024

2.7K
Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

8.4K
Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
10:24

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

16.6K

Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Epileptology

Background:

  • Cognitive interventions for seizure control are under-explored in clinical epileptology.
  • A complex reaction time (CRT) test, triggered by seizure detection, presents a unique research paradigm.

Purpose of the Study:

  • To investigate the effects of a CRT test on seizure frequency and severity.
  • To compare outcomes between subjects receiving the CRT test and those who did not.

Main Methods:

  • A cohort of 14 subjects undergoing epilepsy surgery evaluation received a CRT test.
  • A control group of 37 subjects received the same evaluation without the CRT test.
  • Seizure frequency and severity were compared using t-tests and chi-squared tests.

Main Results:

  • Subjects who underwent the CRT test experienced significantly fewer clinical seizures (8/14) and combined clinical/subclinical seizures (7/14) compared to the control group (p<0.001).
  • The CRT group had a longer monitoring duration (8.9 days vs. 6.7 days), a statistically significant difference (p~0.04).
  • One subject exhibited reduced seizure severity during CRT testing (p<0.001).

Conclusions:

  • Seizure frequency reduction appears to be a beneficial effect of the CRT test.
  • The findings support a hypothetical "competition for neuronal processing time" mechanism for seizure control.
  • The CRT test demonstrates potential as a cognitive intervention for managing epilepsy.