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Severe bronchopulmonary dysplasia is associated with higher fluid intake in very low-birth-weight infants: a

Mindy Ming-Huey Guo1, Ching-Hung Chung2, Feng-Shun Chen1

  • 1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan.

American Journal of Perinatology
|June 11, 2014
PubMed

Insights

Very low-birth-weight infants receiving higher fluid intake in early life face increased risk of severe bronchopulmonary dysplasia. Higher fluid intake from days 2-4 is a significant risk factor for developing severe BPD.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant cause of morbidity in very low-birth-weight infants (VLBWI).
  • Early life fluid management is crucial for VLBWI outcomes.

Purpose of the Study:

  • To investigate the association between early fluid intake and the severity of bronchopulmonary dysplasia (BPD) in VLBWI.

Main Methods:

  • Retrospective chart review of 75 VLBWI (gestational age < 32 weeks, birth weight < 1,500 g).
  • Analysis of demographic, clinical data, maternal risk factors, and fluid intake in the first 4 days of life.

Main Results:

  • Severe BPD was associated with lower gestational age, lower birth weight, surfactant use, patent ductus arteriosus (PDA), and pulmonary hemorrhage.
  • Higher fluid intake from the 2nd to 4th days of life (346.44 ± 42.38 mL/kg) was significantly associated with severe BPD compared to lower intake (323.91 ± 27.62 mL/kg).
  • A fluid intake cutoff of 345 mL/kg from days 2-4 was identified as a significant risk factor for severe BPD, even after logistic regression analysis.

Conclusions:

  • Higher fluid intake in VLBWI during the 2nd to 4th days of life is a significant risk factor for developing severe BPD.
  • This finding highlights the importance of careful fluid management in the early neonatal period for VLBWI.
Abstract

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