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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Gene-Environment Interactions01:20

Gene-Environment Interactions

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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
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Related Experiment Video

Updated: Apr 28, 2026

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
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[Epigenetics, environment and asthma].

Guadalupe Rico-Rosillo1, Gloria Bertha Vega-Robledo, Raúl Silva-García

  • 1División de Investigación, Facultad de Medicina, UNAM, Av. Universidad 3000, circuito escolar s/n, 04510 México, DF. gricor12@yahoo.com.mx.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|June 11, 2014
PubMed
Summary

Epigenetics explains how environmental factors like pollution and diet influence asthma development. DNA methylation, histone modification, and microRNA expression are key epigenetic mechanisms affected by external stimuli, impacting asthma susceptibility.

Keywords:
AcetylationAsthmaEnvironmentalEpigeneticsMethylation

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Area of Science:

  • Immunology
  • Genetics
  • Environmental Health

Context:

  • Asthma is a complex respiratory disease with genetic and environmental influences.
  • Current genetic studies identify only a portion of asthma's heritability and susceptibility.
  • Epigenetic mechanisms offer insights into environmental triggers for complex diseases like asthma and allergies.

Purpose:

  • To review the role of environmental factors in asthma development.
  • To analyze the relationship between environmental exposures and epigenetic mechanisms.
  • To explore how epigenetics contributes to asthma's pathogenesis and inheritance.

Summary:

  • Environmental factors (e.g., diet, pollution, smoking) can alter gene expression through epigenetic modifications.
  • Key epigenetic mechanisms include DNA methylation, histone post-translational modifications, and microRNA expression.
  • These environmentally influenced epigenetic changes are implicated in asthma development and susceptibility.

Impact:

  • Provides a framework for understanding how environmental exposures contribute to asthma.
  • Highlights the importance of epigenetics in bridging the gap between genes and environment in asthma.
  • Suggests potential targets for asthma prevention and treatment by modulating epigenetic pathways.