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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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[NERVOUS REGULATION OF BILIARY TRACT MOTILITY].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2018
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THE ROLE OF BILE ACIDS IN THE REGULATION OF LIPID AND CARBOHYDRATE METABOLISM IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE AND DIABETES TYPE2.

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Updated: Apr 28, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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Experimental osteoporosis and its correction.

A V Petrakov1, V N Yarygin, A E Lychkov

  • 1Central Research Institute of Gastroenterology, Department of Health of Moscow, N. I. Pirogov Russian National Research Medical University, Moscow, Russia.

Bulletin of Experimental Biology and Medicine
|June 12, 2014
PubMed
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This study investigated osteoporosis in rats induced by omeprazole or serotonin. Mesenchymal stem cell treatment effectively reduced osteoporosis severity in these models.

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Area of Science:

  • Biomedical research
  • Bone biology
  • Hepatic fibrosis research

Background:

  • Osteoporosis is a significant health concern.
  • Hepatic fibrosis can impact bone metabolism.
  • Omeprazole and serotonin have been implicated in bone health changes.

Purpose of the Study:

  • To model osteoporosis in rats using chronic omeprazole or serotonin administration.
  • To investigate bone tissue status in rats with experimental hepatic fibrosis.
  • To evaluate the therapeutic effect of mesenchymal stem cells on osteoporosis.

Main Methods:

  • Osteoporosis was induced in rats via 6-month treatment with omeprazole or serotonin.
  • Bone tissue and serum biochemical markers were analyzed.
  • Mesenchymal stem cells were administered for 6 months.

Main Results:

  • Chronic omeprazole or serotonin treatment led to osteoporosis.
  • Hepatic fibrosis influenced bone tissue status.
  • Mesenchymal stem cell therapy demonstrated a reduction in osteoporosis severity.

Conclusions:

  • Mesenchymal stem cells show potential in mitigating osteoporosis.
  • The study highlights the complex interplay between hepatic fibrosis, drug treatments, and bone health.
  • Further research into therapeutic strategies for drug-induced osteoporosis is warranted.