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Structure factor model for understanding the measured backscatter coefficients from concentrated cell pellet
Emilie Franceschini1, Régine Guillermin1, Franck Tourniaire1
1Laboratoire de Mécanique et d'Acoustique LMA - CNRS UPR 7051, Aix-Marseille Université, Centrale Marseille, 13402 Marseille Cedex 20, France.
The Journal of the Acoustical Society of America
|June 12, 2014
Summary
The structure factor model (SFM) best explains ultrasonic scattering from concentrated cell pellets, outperforming fluid-filled sphere and particle models. This finding aids in accurately characterizing biological tissues using ultrasound.
Area of Science:
- Biophysics
- Acoustics
- Biomaterials
Background:
- Ultrasonic backscatter coefficient (BSC) is crucial for characterizing biological tissues.
- Modeling ultrasonic scattering from concentrated cell suspensions requires appropriate models.
Purpose of the Study:
- To compare the suitability of three scattering models (FFSM, PM, SFM) for concentrated cell pellets.
- To develop a parameter estimation procedure for scatterer size and impedance contrast.
- To validate the models using K562 and Chinese hamster ovary cell biophantoms.
Main Methods:
- Ultrasonic backscatter coefficient (BSC) measurements were conducted on cell pellet biophantoms.
- Three scattering models (FFSM, PM, SFM) were evaluated.
- A parameter estimation procedure was developed to determine scatterer properties.
Main Results:
- The structure factor model (SFM) demonstrated superior data fitting compared to the fluid-filled sphere model (FFSM) and particle model (PM).
- The SFM provided more accurate scatterer size estimates for concentrated cell pellets.
- The developed parameter estimation procedure effectively explained measured BSCs across different cell concentrations and frequencies.
Conclusions:
- The structure factor model (SFM) is the most suitable model for analyzing ultrasonic scattering from concentrated cell pellet biophantoms.
- Accurate characterization of biological tissues using ultrasound can be improved by employing the SFM.
- The study provides a robust method for estimating scatterer properties from ultrasonic measurements.
