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Risperidone long-acting injectable for maintenance therapy in bipolar disorder: An open-label pilot study
Peter Bräunig1, Emilio Sacchetti, Rossella Medori
1Klinik für Psychiatrie und Psychotherapie, Vivantes Humboldt-Klinikum, Berlin, Germany.
International Journal of Psychiatry in Clinical Practice
|June 12, 2014
Summary
Risperidone long-acting injectable (RLAI) effectively maintained symptom control in stable bipolar disorder patients over six months. Patient satisfaction significantly improved, indicating RLAI
Area of Science:
- Psychiatry
- Pharmacology
Background:
- Bipolar disorder requires continuous antipsychotic management.
- Transitioning to long-acting injectables (LAI) can address adherence issues.
Purpose of the Study:
- To assess the maintained efficacy of risperidone long-acting injectable (RLAI) in stable bipolar I disorder patients.
- To evaluate symptom control and patient satisfaction during a 6-month RLAI treatment period.
Main Methods:
- A subgroup of 16 adult bipolar I disorder patients from the StoRMi trial were analyzed.
- Patients received RLAI (25mg, potentially increased) every 14 days for 6 months.
- Clinical Global Impression (CGI) Disease Severity and ESRS scores were assessed.
Main Results:
- 12 out of 16 patients completed the 6-month trial.
- Significant reduction in disease symptoms (CGI Disease Severity, P=0.0225) was observed.
- Patient satisfaction significantly increased, with 36% reporting "very good" satisfaction at endpoint.
Conclusions:
- Risperidone long-acting injectable (RLAI) demonstrated maintained efficacy in controlling bipolar disorder symptoms over 6 months.
- RLAI improved patient satisfaction compared to previous therapies.
- Further controlled studies are warranted to confirm these findings.
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