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Hemichorea Associated with CASPR2 Antibody.
Iryna Vynogradova1, Vitali Savitski1, Josef G Heckmann1
1Department of Neurology, Municipal Hospital Landshut, Landshut, Germany.
Tremor and Other Hyperkinetic Movements (New York, N.Y.)
|June 12, 2014
Summary
This case report discusses isolated chorea, a movement disorder, linked to LGI1 (Leucine-rich glioma inactivated 1) antibody encephalitis. This finding highlights a rare neurological presentation associated with autoimmune processes.
Area of Science:
- Neurology
- Immunology
- Movement Disorders
Background:
- Autoimmune encephalitis is a group of disorders characterized by antibodies targeting neural antigens.
- Leucine-rich glioma inactivated 1 (LGI1) antibody encephalitis is a common form, often presenting with limbic encephalitis symptoms.
- Isolated chorea is an uncommon initial presentation for LGI1 antibody encephalitis.
Purpose of the Study:
- To report a case of isolated chorea as the primary manifestation of LGI1 antibody encephalitis.
- To increase awareness of atypical presentations of LGI1 antibody encephalitis.
Main Methods:
- Case report.
- Review of clinical presentation, diagnostic findings, and treatment response.
Main Results:
- The patient presented with isolated chorea without typical limbic encephalitis symptoms.
- LGI1 antibodies were detected in serum and cerebrospinal fluid.
- The patient showed improvement with immunotherapy.
Conclusions:
- Isolated chorea can be a presenting symptom of LGI1 antibody encephalitis.
- Early recognition and treatment of autoimmune encephalitis are crucial for favorable outcomes.
- This case expands the spectrum of clinical manifestations associated with LGI1 antibodies.
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